Most of you are familiar with Monsanto the seed giant. All of you are familiar with the cruciferous vegetable, broccoli. Some of you may know that Monsanto released a variety of broccoli last year purported to be better for you, called “Beneforté.” One year later, an article by a newly-registered dietitian named Andy Bellatti appeared on Grist to bust Monsanto’s ‘better’ broccoli, which some of you may have noticed. But none of you who finish reading this post will believe that Bellatti “busted” the Beneforté broccoli at all. The only thing he busted was his own research, journalistic, and dietetic integrity.

Glusosino-What?

There has been considerable interest in investigating the composition of foods to determine what parts of them can contribute to our health. (And what detracts from it too.)  Broccoli and other cruciferous vegetables have garnered considerable attention for their effects on the development of cancer. Research has revealed an important class of compounds called Glucosinolates, particularly one known as Glucoraphanin. When this sulfur-containing compound is metabolized by a plant enzyme called Myrosinase, it becomes one of two different compounds: Sulforaphane and Sulforaphane Nitrile. These two Isothiocyanates have been found to have preventative effects against cancer, and Sulforaphane is by far the more potent of the two. And this year, an important paper found that even the precursor, Glucoraphanin, also has important effects.

I apologize for the dizzying array of chemical names. So let me see if I can make them easier to understand. Glucosinolates include many similar kinds of compounds, and Glucoraphanin at the top of the picture here is one example. It gets the Gluco- from having a glucose sugar molecule bonded to it, which is that ring on the right hand side. Isothiocyanates are another class of compounds, and the main example is Sulforaphane. You can distinguish them by that N=C=S group on the Sulforaphane above. There are many Glucosinolates and Isothiocyanates important for this topic, so rather than bring up so many names I’ll only talk about the groups (end in -ates) and the two specific ones I mentioned (Glucoraphanin and Sulforaphane both have -raph- in them).

How do they work? Well, there is a huge amount of research on this topic, and while I could send you on a journey through a google or PubMed search, there are a few clear things that we know.

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