Want to study relative risks of GE?

Last Thursday, the United States Department of Agriculture (USDA) and the National Institute of Food and Agriculture (NIFA) posted a new grant – one that readers of Biofortified might be interested to read about. Called the Biotechnology Risk Assessment Grants Program, (PDF) this grant for up to $1 million for each project is for scientists who want to study the environmental risks of genetic engineering in agriculture.

What kinds of environmental risks? Things like basic genetics research, comparing breeding to biotechnology, and downstream effects of environmental release. There is even a section for it you want to submit a research proposal to study co-existence between GE and non-GE crops. You could even study pyramided, or “stacked” GE crops and compare them to single-transgene varieties. So many possibilities.

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The regulatory bottleneck for biotech specialty crops

We often hear that there are only two genetically engineered traits on the market – Roundup Ready and Bt. And, for the most part, that’s correct. There are a few other commercialized traits, such as virus resistant papaya and squash, but why aren’t there more? We see all sorts of papers about awesome genetically engineered traits, from nemotode resistance to nutritional enhancement to really specialized traits like nicotine free tobacco and allergen free peanuts. There are so many traits that we even started a list at Biofortified in an attempt to keep track of them all.

These traits have been developed and tested for efficacy, often with public funding, but haven’t make it to the commercialization stage. All that’s needed is a little breeding to get these traits ready for market. Why don’t we see them in the grocery store? UC Davis researchers Kent Bradford and Jamie Miller have collected a huge amount of data on genetically engineered traits and presented it in their recent paper The regulatory bottleneck for biotech specialty crops. It’s a short but insightful piece. Don’t forget to check out the supplementary material that has lists of all the different traits they found described in the literature.

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Barriers to GE Hort Crop Commercialization

Last week a workshop at the International Horticultural Congress in Lisbon, Portugal featured a series of speakers known for their work in transgenic  technology.  I’ll summarize these in the next few posts.  Today’s post addresses an important question- why are there few horticultural (basically non-agronomic fruits and vegetables) transgenic crops available, at least relative to corn, soy and other huge agronomic crops?  These are the capsules of flavor and nutrition truly necessary in a diverse diet, yet they suffer tremendous challenges to production and distribution.  Transgenic technologies could deliver great benefits.

The issue was approached by Dr. Ralph Scorza from the USDA Appalachian Fruit Research Station. I’ve known of Dr. Scorza’s outstanding work for almost two decades.  Years ago he sought a solution to the plum pox virus (PPV), the causative agent of a devastating disease called Sharka. The disease affects stone fruits (peaches, apricots, others) and can destroy whole orchards and decimate natural populations.  While breeding solutions are being pursued with timelines measured in decades, PPV can now be mitigated with Scorza’s solution by grafting a stonefruit scion to the transgenic rootstock.  Works like a charm, and the fruit are not transgenic.

The solution was introduction of a gene encoding the coat protein of PPV.  When overexpressed in plums (because they are routinely transformed in the Scorza Lab), the plant became immune to the disease, almost like a vaccination.  While this was interesting science it was not viewed as an application, that is until PPV was identified in the United States.  While the disease was successfully controlled with quarantine, the development of PPV-resistant plums (a cultivar known as “Honeysweet”) was initiated as a solution in future outbreaks.

Years later in 2010, the Honeysweet cultivar has found approval.  It is a true minority, as very few horticultural crops are ever approved, reserving much of the focus for major agronomical crops like soy and corn.  To date, only 6% of de-regulated crops are horticultural and only 1% had viable commercial potential.  Of that, 0.2 were crops other than tomato and potato. Therein lies the question, why are transgenic technologies not approved (or even pursued) in fruits and vegetables?

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Sugar beet biology

Roundup Ready sugar beets have been back in the news due to the decision by Judge White to revoke approval. As I understand it, the USDA conduced an Environmental Assessment for Roundup Ready sugar beets but did not conduct an Environmental Impact Statement. According to regulation, an EA is sufficient if potential harm is found to be minimal, but an EIS is needed for anything that is less well understood, such as a new trait (and this is hardly a new trait). After reading the EA, I agree with the USDA that the potential environmental harm is minimal, and I think the potential economic harm is minimal as well, due to some very specific characteristics of beet biology, which I’ll explain in this post, followed by a discussion of mitigation strategies that might be used to control gene flow in beets (sorry, folks, this is going to be another long one).

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To dye or not to dye

Brownfield Ag News America had an interesting blurb on Thurs Feb 12: Maryland may ban certain food colorings.
A couple of bills pending in the Maryland state legislature seek to require labeling and eventually ban some synthetic food colorings. The bills have been pushed by the Center for Science in the Public Interest which charges the food dyes have been linked to ADHD, or attention deficit hyperactivity disorder.

The Maryland bills deal with the dyes: Blue 1; Blue 2; Green 3; Orange B; Red 3; Red 40; Yellow 5 and Yellow 6. One of the bills would prohibit public schools and child care facilities from providing food with the coloring in it. The second bill would require a label warning: The color additives in this food may cause hyperactivity and behavior problems in some children. Use of the dyes would be banned in the state in 2012.

The food industry opposes the bill saying the link to ADHD is based on flawed research while the Food and Drug Administration states there is no scientific evidence to support the claim that the colorings cause hyperactivity.

I’m rather conflicted about this. On the one hand, there really isn’t any science backing the idea that dye causes ADHD, although perhaps there is a genetic predisposition that is exacerbated by the dye. There are studies showing a link between dye and hyperactivity – is that enough of a reason to ban it? Sugars cause tooth decay and diabetes, high-fat and high-sodium foods cause heart disease… if we ban one, shouldn’t we ban, restrict use of, or at least paste a warning label on the others?
On the other hand, do we need food dye? Shouldn’t food just be the color it is? What about other additives, like sodium benzoate? Do we need those more or less than, say, trans-fats?
Risk benefit analysis may tell us the answer, but we need regulators to actually think through it.

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